Measuring serum zonulin, researchers investigated how intestinal permeability changes prior to celiac disease autoimmunity. They also analyzed how environmental factors such as infections and antibiotics affect levels of zonulin. Read the Pediatrics article or watch this video abstract:
Researchers conducted a meta-analysis exploring the correlation between anti-tTG antibody levels and the histological severity of celiac disease. They found a positive correlation between increased anti-tTG levels and histological severity, showing a trend of increasing anti-tTG levels associated with higher Marsh scores. Click here to read more.
A new e-publication from Frontiers in Nutrition, Recent Breakthrough in Gluten Contamination, is a compilation of 9 articles that "...provide insights on gluten assessment to ensure safe food choices are available for gluten-intolerant consumers. The topics covered in this publication range from gluten measurement to its complex proteomic analysis using various analytical tools." Click here to read this publication.
Researchers suggest that DONQ52, a multispecific antibody targeting the HLA-DQ2.5 serotype complex as well as multiple gluten peptides, has the potential to selectively inhibit the immune response to gluten in celiac disease. DONQ52 is designed to shut down the T-cell response, the fundamental cause of symptoms. More research and clinical testing of DONQ52 is needed. Click here to read more.
Researchers who investigated the effects of expectancy versus actual gluten intake on symptoms in people with non-celiac gluten sensitivity found that the combination of expectancy and actual gluten intake had the largest effect on gastrointestinal symptoms. They concluded that further research into the possible involvement of the gut–brain interaction in non-celiac gluten sensitivity. Click here to read more.